Patent details 
	
	
	
		
		
			EP2576510
		 
		
			
				Title:
				
					PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER.
				 
			
			
		
	
	
		
		
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				Basic Information 
				
					Publication number: 
					EP2576510 
					
						WO Application Number: 
						Type: 
					
						
							European Patent Granted for NL 
						
						
						
						
						
					
					
					
					Status: 
					
						
							Patent in Force 
						
						
						
						
					
					
					
						Publication Title: 
						Title When Made Available For Viewing: 
						Reason Lapsed: 
						 
				
					Application number: 
					EP11726581.9 
					
						WO Publication Number: 
						EPO Publication Language: 
						English 
					
					
					
						SPC Number: 
						
							
						 
					
					
					First Applicant Residence Country: 
					United States of America (US) 
					
						Publications: 
						 
				
				
				
				
				
				
				Dates 
				
					Filing date: 
					03/06/2011 
					
					
					Grant date: 
					29/04/2015 
					
					
						EP Publication Date: 
						29/04/2015 
						WO Publication Date: 
						Claims Translations Received Date: 
						Claims Translation B1 Received Date: 
						Claims Translation B2 Received Date: 
						Claims Translation B3 Received Date: 
						Lapsed By Non Payment Annual Fee Date: 
					Renunciation Date: 
					NullificationDate: 
					Published: 
						Due To Cession Date: 
						 
				
					Registration date: 
					29/04/2015 
					
						EP B1 Publication Date: 
						29/04/2015 
						EP B2 Publication Date: 
						EP B3 Publication Date: 
						Description Translation B1 Received Date: 
						02/07/2015 
						Description Translation B2 Received Date: 
						Description Translation B3 Received Date: 
						Expiration date: 
						
					
					02/06/2031 
					Lapsed By Expiration Date: 
					Revocation Date: 
						Invalidity Date: 
						Response To Novelty Search Report Received: 
						Patent Granting Request: 
						Lapsed date: 
						 
				
				
				
					Applicant/holder  
					
						
						
							From: 
							29/04/2015 
						 
						
							  
							  
						 
						
							  
							
								Name: 
								Amgen Inc. 
							 
							
								Address: 
								One Amgen Center Drive M/S 28-2-C, THOUSAND OAKS, CA 91320, United States of America (US) 
							 
						
						
					
				
				
				
				
				
				
				
					Domicile Holder 
					
						
						
							Name: 
							ir. A. Blokland c.s. 
							From: 
							29/04/2015 
						 
						
							Address: 
							Algemeen Octrooi- en Merkenbureau B.V.
Postbus 645, 5600 AP, Eindhoven, Netherlands (NL) 
							To: 
							 
					
				
				
				
					Inventor 
					
						
							1 
						
						
							Name: 
							BARTBERGER, Michael David 
						 
						
							Address: 
							SHERMAN OAKS, CALIFORNIA 91423, United States of America (US) 
						 
					
						
							2 
						
						
							Name: 
							GONZALEZ BUENROSTRO, Ana 
						 
						
							Address: 
							SAN MATEO, CALIFORNIA 94401, United States of America (US) 
						 
					
						
							3 
						
						
							Name: 
							BECK, Hilary Plake 
						 
						
							Address: 
							SAN CARLOS, CALIFORNIA 94070, United States of America (US) 
						 
					
						
							4 
						
						
							Name: 
							CHEN, Xiaoqi 
						 
						
							Address: 
							PALO ALTO, CALIFORNIA 94303, United States of America (US) 
						 
					
						
							5 
						
						
							Name: 
							CONNORS, Richard Victor 
						 
						
							Address: 
							PACIFICA, CALIFORNIA 94044, United States of America (US) 
						 
					
						
							6 
						
						
							Name: 
							DEIGNAN, Jeffrey 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94131, United States of America (US) 
						 
					
						
							7 
						
						
							Name: 
							DUQUETTE, Jason 
						 
						
							Address: 
							MILLBRAE, CALIFORNIA 90403, United States of America (US) 
						 
					
						
							8 
						
						
							Name: 
							EKSTEROWICZ, John 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94131, United States of America (US) 
						 
					
						
							9 
						
						
							Name: 
							FISHER, Benjamin 
						 
						
							Address: 
							SAN MATEO, CALIFORNIA 94403, United States of America (US) 
						 
					
						
							10 
						
						
							Name: 
							FOX, Brian Matthew 
						 
						
							Address: 
							BRISBANE, CALIFORNIA 94005, United States of America (US) 
						 
					
						
							11 
						
						
							Name: 
							FU, Jiasheng 
						 
						
							Address: 
							FOSTER CITY, CALIFORNIA 94404, United States of America (US) 
						 
					
						
							12 
						
						
							Name: 
							FU, Zice 
						 
						
							Address: 
							FOSTER CITY, CALIFORNIA 94404, United States of America (US) 
						 
					
						
							13 
						
						
							Name: 
							GONZALEZ LOPEZ DE TURISO, Felix 
						 
						
							Address: 
							SAN MATEO, CALIFORNIA 94402, United States of America (US) 
						 
					
						
							14 
						
						
							Name: 
							GRIBBLE, JR., Michael William 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94110, United States of America (US) 
						 
					
						
							15 
						
						
							Name: 
							GUSTIN, Darin James 
						 
						
							Address: 
							HALF MOON BAY, CALIFORNIA 94019, United States of America (US) 
						 
					
						
							16 
						
						
							Name: 
							HEATH, Julie Anne 
						 
						
							Address: 
							ORINDA, CALIFORNIA 94563, United States of America (US) 
						 
					
						
							17 
						
						
							Name: 
							HUANG, Xin 
						 
						
							Address: 
							WELLESLY, MASSACHUSETTS 02481, United States of America (US) 
						 
					
						
							18 
						
						
							Name: 
							JIAO, Xianyun 
						 
						
							Address: 
							BELMONT, CALIFORNIA 94002, United States of America (US) 
						 
					
						
							19 
						
						
							Name: 
							JOHNSON, Michael 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94114, United States of America (US) 
						 
					
						
							20 
						
						
							Name: 
							KAYSER, Frank 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94114, United States of America (US) 
						 
					
						
							21 
						
						
							Name: 
							KOPECKY, David John 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94107, United States of America (US) 
						 
					
						
							22 
						
						
							Name: 
							LAI, Sujen 
						 
						
							Address: 
							BURLINGAME, CALIFORNIA 94010, United States of America (US) 
						 
					
						
							23 
						
						
							Name: 
							LI, Yihong 
						 
						
							Address: 
							MILLBRAE, CALIFORNIA 94030, United States of America (US) 
						 
					
						
							24 
						
						
							Name: 
							LI, Zhihong 
						 
						
							Address: 
							MILLBRAE, CALIFORNIA 94030, United States of America (US) 
						 
					
						
							25 
						
						
							Name: 
							LIU, Jiwen 
						 
						
							Address: 
							FOSTER CITY, CALIFORNIA 94404, United States of America (US) 
						 
					
						
							26 
						
						
							Name: 
							LOW, Jonathan Dante 
						 
						
							Address: 
							TARZANA, CALIFORNIA 91356, United States of America (US) 
						 
					
						
							27 
						
						
							Name: 
							LUCAS, Brian Stuart 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94118, United States of America (US) 
						 
					
						
							28 
						
						
							Name: 
							MA, Zhihua 
						 
						
							Address: 
							FOSTER CITY, CALIFORNIA 94404, United States of America (US) 
						 
					
						
							29 
						
						
							Name: 
							MCGEE, Lawrence 
						 
						
							Address: 
							PACIFICA, CALIFORNIA 94044, United States of America (US) 
						 
					
						
							30 
						
						
							Name: 
							MCINTOSH, Joel 
						 
						
							Address: 
							PACIFICA, CALIFORNIA 94044, United States of America (US) 
						 
					
						
							31 
						
						
							Name: 
							MCMINN, Dustin 
						 
						
							Address: 
							PACIFICA, CALIFORNIA 94044, United States of America (US) 
						 
					
						
							32 
						
						
							Name: 
							MEDINA, Julio Cesar 
						 
						
							Address: 
							SAN CARLOS, CALIFORNIA 94070, United States of America (US) 
						 
					
						
							33 
						
						
							Name: 
							MIHALIC, Jeffrey Thomas 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94107, United States of America (US) 
						 
					
						
							34 
						
						
							Name: 
							OLSON, Steven Howard 
						 
						
							Address: 
							MILLBRAE, CALIFORNIA 94030, United States of America (US) 
						 
					
						
							35 
						
						
							Name: 
							REW, Yosup 
						 
						
							Address: 
							FOSTER CITY, CALIFORNIA 94404, United States of America (US) 
						 
					
						
							36 
						
						
							Name: 
							ROVETO, Philip Marley 
						 
						
							Address: 
							SAN FRANCISCO, CALIFORNIA 94131, United States of America (US) 
						 
					
						
							37 
						
						
							Name: 
							SUN, Daqing 
						 
						
							Address: 
							FOSTER CITY, CALIFORNIA 94404, United States of America (US) 
						 
					
						
							38 
						
						
							Name: 
							WANG, Xiaodong 
						 
						
							Address: 
							MILLBRAE, CALIFORNIA 94030, United States of America (US) 
						 
					
						
							39 
						
						
							Name: 
							WANG, Yingcai 
						 
						
							Address: 
							MILLBRAE, CALIFORNIA 94030, United States of America (US) 
						 
					
						
							40 
						
						
							Name: 
							YAN, Xuelei 
						 
						
							Address: 
							FOSTER CITY, CALIFORNIA 94404, United States of America (US) 
						 
					
						
							41 
						
						
							Name: 
							YU, Ming 
						 
						
							Address: 
							FOSTER CITY, CALIFORNIA 94404, United States of America (US) 
						 
					
						
							42 
						
						
							Name: 
							ZHU, Jiang 
						 
						
							Address: 
							PALO ALTO, CALIFORNIA 94303, United States of America (US) 
						 
					
				
				
				
				
				
				
				
				
				
					Priority 
					
						
							1 
						
						
							Priority Patent Number: 
							351827 P 
							Priority Date: 
							04/06/2010 
							
						 
						
							Priority Country: 
							United States of America (US) 
							
						 
					
						
							2 
						
						
							Priority Patent Number: 
							352322 P 
							Priority Date: 
							07/06/2010 
							
						 
						
							Priority Country: 
							United States of America (US) 
							
						 
					
						
							3 
						
						
							Priority Patent Number: 
							201161452578 P 
							Priority Date: 
							14/03/2011 
							
						 
						
							Priority Country: 
							United States of America (US) 
							
						 
					
				
				
				
				
				
					Classification 
					
						
							Main IPC Class: 
							
								
									C07D 211/40 ;
							 
						
						
							IPC or IDT classification: 
							
								
									
									
										A61K 31/4412 ;
								
									
									
										A61P 35/00 ;
								
									
									
										C07D 279/02 ;
								
									
									
										C07D 401/04 ;
								
									
									
										C07D 401/06 ;
								
									
									
										C07D 401/12 ;
								
									
									
										C07D 407/04 ;
								
									
									
										C07D 407/06 ;
								
									
									
										C07D 409/04 ;
								
									
									
										C07D 413/06 ;
								
									
									
										C07D 417/06 ;
								
									
									
										C07D 471/20 ;
								
									
									
										C07D 498/08 ;
								
									
									
										C07D 498/20 ;
								
							 
						
					 
				
				
				
					Publication 
					
						Bulletin 
						
							
								1 
							
							
								Bulletin Heading: 
								EP3 
								Journal edition number: 
								2015/29 
							 
							
								Publication date: 
								15/07/2015 
								Description: 
								European patents granted for the Netherlands in which a translation was filed ex Article 52 par. 1 of the NL Patent Law 1995 
							 
						
							
								2 
							
							
								Bulletin Heading: 
								EP2 
								Journal edition number: 
								2015/19 
							 
							
								Publication date: 
								06/05/2015 
								Description: 
								European patents granted for the Netherlands 
							 
						
					
					
						European Patent Bulletin 
						
							
							
								Issue number: 
								201518 
							 
							
								Publication date: 
								29/04/2015 
								Description: 
								Grant (B1) 
							 
						
					
				
				
				
				
				
				
				
				
				
				
				
				
				
					
					Annual Fee 
					
						Annual Fee(s) Due Date: 
						 30/06/2026 
						
						Annual Fee Number: 
						 16 
						
							Annual Fee Amount: 
							 1000 Euro 
						
						
					 
					
						Last Annual Payment Date: 
						 26/06/2025 
						Last Annual Fee Paid Number: 
						 15 
						
							Last Annual Fee Paid Amount: 
							 900 Euro 
						
						Payer: 
						 Computer Packages Inc. (CPI) 
					 
				
				
				
			 
			
			
				
					
					
						Filing date 
						Document type 
						Document Description 
						Number of pages 
						File Type 
						 
					 
					
					
						
							
								09/07/2015 
									
								
									
										
										
											
												
													
													
														 Outgoing Correspondence
													
												
											 
										
									
									 
								 Outgoing Letter 
								
									
										
										
											 1
										
									
								 
								
									
										
										
											
												PDF
											
										
									
								 
								/1/8/5/6/2/0511726581/docs/ep11726581.9_4_outgoingcorrespondence20150709.pdf 
							 
						
							
								02/07/2015 
									
								
									
										
										
											
												
													
													
														 Incoming Correspondence Paper
													
												
											 
										
									
									 
								 Accompanying letter incoming document 
								
									
										
										
											 2
										
									
								 
								
									
										
										
											
												PDF
											
										
									
								 
								/1/8/5/6/2/0511726581/docs/ep11726581.9_0_incomingcorrespondencepaper20150702.pdf 
							 
						
							
								02/07/2015 
									
								
									
										
										
											
												
													
													
														 Incoming Correspondence Paper
													
												
											 
										
									
									 
								 Accompanying letter incoming document 
								
									
										
										
											 1
										
									
								 
								
									
										
										
											
												PDF
											
										
									
								 
								/1/8/5/6/2/0511726581/docs/ep11726581.9_1_incomingcorrespondencepaper20150702.pdf 
							 
						
							
								02/07/2015 
									
								
									
										
										
											
												
													
													
														 Claims
													
												
											 
										
									
									 
								 Translated claims 
								
									
										
										
											 1
										
									
								 
								
									
										
										
											
												PDF
											
										
									
								 
								/1/8/5/6/2/0511726581/docs/ep11726581.9_2_claims20150702.pdf 
							 
						
							
								02/07/2015 
									
								
									
										
										
											
												
													
													
														 Outgoing Correspondence
													
												
											 
										
									
									 
								 Outgoing Letter 
								
									
										
										
											 1
										
									
								 
								
									
										
										
											
												PDF
											
										
									
								 
								/1/8/5/6/2/0511726581/docs/ep11726581.9_3_outgoingcorrespondence20150702.pdf